![]() ![]() The findings in the literature confirm associations between some of the extracted omics and breast cancer prognosis and survival including CDCA5, IL17RB, MUC2, NOD2 and NXPH4 from the gene expression dataset MED30, RAD21, EIF3H and EIF3E from the CNA dataset and CENPA, MACF1, UGT2B7 and SEMA3B from the mRNA dataset.īioinformatics breast cancer classification high-dimensional embedding multi-omics prognosis residual neural network survival. The proposed model outperformed the other methods with an accuracy of 98.48%, and the area under the curve (AUC) equals 0.9999. We evaluated this model and compared it to different high-dimensional embedding techniques and neural network combinations. The aim of this work was to (i) extract multi-omics biomarkers that are associated with the prognosis and prediction of breast cancer survival and (ii) build a prediction model for multi-class breast cancer NPI classes. The model creates a gene similarity network (GSN) map for each omic using t-distributed stochastic neighbor embedding ( t-SNE) before being merged into the residual neural network (ResNet) classification model. The dataset consists of three -omics: gene expression, copy number alteration (CNA), and mRNA from 1885 female patients. High-dimensional embedding techniques are incorporated to present the features in the lower dimension, i.e., in a 2-dimensional map. In this paper, wehave described our use of various machine learning ap-proaches to the complex problem of predicting breastcancer survivability rate, with the data provided throughthe DREAM Breast Cancer Prognosis Challenge. Next-generation sequencing advancements have led to. Histological grade is reported using the Nottingham Score. REFERENCES 5 7 Discussion Breast cancer prognosis presents an important challengewith many real life implications. The NPI value is calculated based on the size of the tumor, the number of lymph nodes, and the tumor grade. The availability of multi-omics data triggered the challenge of integrating and analyzing these various biological measures to understand the progression of the diseases. A pathology category classification (B1-5) is used by the UK National Health Service Breast. Next-generation sequencing advancements have led to measuring different biological indicators called multi-omics data. The NPI value is calculated based on the size of the tumor, the number of lymph nodes, and the tumor grade. The Nottingham Prognostics Index (NPI) is a prognostics measure that predicts operable primary breast cancer survival. ![]()
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